Here are 50+ Supplements & Medications for Longevity: Increasing Human lifespan
There are 5 sections of supplementation split by complexity:
SECTION 1: Special compounds not found/bioavailable in food:
- NAD+: NAD+ is a coenzyme that is essential for cellular function. It has been shown to extend lifespan in animals and is currently being studied in clinical trials as a potential treatment for aging.
- Sirtuins: Sirtuins are a class of proteins that have been shown to have anti-aging effects. They can be activated by exercise, calorie restriction, and certain supplements.
- Metformin: Metformin is a drug used to treat type 2 diabetes. It has been shown to extend lifespan in animals and is currently being studied in clinical trials as a potential treatment for aging.
- Trans Resveratrol: Trans Resveratrol is a more bioavailable form of reservatol found in red wine, grapes, and other foods. It has been shown to have a number of health benefits, including reducing inflammation and protecting against cancer.
- Ubiquinol / Coenzyme Q10: Coenzyme Q10 is an antioxidant that is found in all cells in the body. It has been shown to improve heart health and may also help to protect against a number of chronic diseases.
Ubiquinol is the active form of CoQ10. It has been shown to improve heart health and reduce the risk of Parkinson's disease. - Nerve growth factor (NGF): NGF is a protein that is essential for the growth and maintenance of nerve cells. NGF supplements have been shown to improve cognitive function and reduce the risk of Alzheimer's disease and dementia.
- Rapamycin: Rapamycin is an immunosuppressant drug that has been shown to extend lifespan in animals. It is currently being studied in clinical trials as a potential treatment for aging.
- Aspirin: Aspirin is a blood thinner that has been shown to reduce the risk of heart disease and stroke. It may also help to extend lifespan.
- GABA: GABA is a neurotransmitter that helps to calm the body and mind. It has been shown to improve sleep quality and reduce anxiety.
- DHEA: DHEA is a hormone that is produced naturally by the body. It has been shown to improve cognitive function and reduce the risk of age-related diseases.
- Carnosine: Carnosine is a compound found in muscle tissue. It has antioxidant and anti-inflammatory properties. It may help to protect against muscle damage and improve cognitive function. It has been shown to protect against age-related diseases, such as Alzheimer's disease and Parkinson's disease.
- Astaxanthin : This powerful antioxidant is found in marine algae and krill. It has been shown to improve cognitive function in people with Alzheimer's disease.
- Taurine: Taurine is an amino acid that is found in high concentrations in the heart, brain, and muscles. It has been shown to protect against heart disease and improve cognitive function.
- Propolis: Propolis is a resinous substance produced by bees. It has anti-inflammatory and antioxidant properties. It may help to protect against cancer, heart disease, and Alzheimer's disease.
- Glucosamine: Glucosamine is a compound that is found naturally in cartilage. It has been shown to reduce pain and improve joint function.
- Probiotics: Probiotics are live bacteria that are beneficial for gut health. They have been shown to improve digestion, boost the immune system, and reduce the risk of some chronic diseases.
- N-acetylcysteine (NAC): NAC is an amino acid that is produced naturally by the body. It has antioxidant and anti-inflammatory properties. It may help to protect against liver damage and improve cognitive function.
- L-arginine: L-arginine is an amino acid that is involved in many bodily functions, including the production of nitric oxide. Nitric oxide helps to relax blood vessels and improve blood flow.
- Carnitine: Carnitine is an amino acid that helps the body produce energy. It may help to improve heart health and reduce the risk of age-related diseases. Acetyl-L-carnitine helps the body produce energy. Some studies have shown that acetyl-L-carnitine may improve cognitive function in people with Alzheimer's disease.
- Agmatine: Agmatine is an amino acid that has been shown to have anti-inflammatory and antioxidant properties. It may help to protect against cancer, heart disease, and Alzheimer's disease.
- L-theanine: L-theanine is an amino acid found in tea. It has been shown to improve focus and reduce stress.
- Alpha-lipoic acid (ALA): This antioxidant helps protect brain cells from damage and may also improve cognitive function.
SECTION 4: Compounds found in plants/fruits/vegatables naturally:
- Curcumin: Curcumin is the active ingredient in turmeric. It has been shown to have anti-inflammatory and antioxidant properties, and it may also help to protect against Alzheimer's disease and other neurodegenerative diseases.
- Sulforaphane: Sulforaphane is a compound found in broccoli and other cruciferous vegetables. It has been shown to protect against cancer and improve cognitive function.
- Terpenoids: Terpenoids are a class of compounds found in plants. They have been shown to have a number of health benefits, including improving heart health, reducing inflammation, and protecting against cancer.
- Fisetin: Fisetin is a flavonoid found in fruits, vegetables, and nuts. It has been shown to protect against age-related diseases, such as Alzheimer's disease and Parkinson's disease.
- Pterostilbene: Pterostilbene is a compound found in blueberries and other fruits. It has been shown to improve cognitive function and reduce the risk of Alzheimer's disease.
- Quercetin: Quercetin is a flavonoid found in onions, apples, and other fruits and vegetables. It has been shown to protect against cancer and improve cognitive function.
- Bromelain: Bromelain is an enzyme found in pineapples. It has been shown to reduce inflammation and improve cognitive function.
- Ginkgo biloba: Ginkgo biloba is a plant that has been used for centuries in traditional Chinese medicine. It has been shown to improve cognitive function and may also help to protect against Alzheimer's disease and dementia.
- Ginseng: Ginseng is a plant that has been used for centuries in traditional Chinese medicine. It has been shown to improve cognitive function and may also help to reduce the risk of some chronic diseases.
- Astaxanthin: Astaxanthin is a carotenoid found in algae and some seafood. It has powerful antioxidant and anti-inflammatory properties. It may help to protect against cancer, heart disease, and Alzheimer's disease.
- Berberine: Berberine is a compound found in plants such as goldenseal and barberry. It has anti-inflammatory and antioxidant properties. It may help to lower blood sugar levels and improve insulin sensitivity.
- oligomeric proanthocyanidins (OPCs) - Grape seed extract contains these antioxidants. OPCs may help to protect against cancer, heart disease, and Alzheimer's disease.
- Kava kava: Kava kava is a plant extract that has been shown to reduce anxiety and improve sleep quality.
- Icariin: Icariin is a compound found in the herb Epimedium. It has been shown to improve erectile function and increase testosterone levels.
- Melatonin: Melatonin is a hormone that helps to regulate sleep. It has been shown to improve sleep quality and may help to extend lifespan. Its naturally present in bananas and pineapples.
- Bilberry : This berry contains antioxidants that may help protect brain cells from damage. Some studies have shown that bilberry may improve cognitive function in people with Alzheimer's disease.
- Bacopa monnieri : This herbal extract is thought to improve cognitive function by increasing the production of brain-derived neurotrophic factor (BDNF), a protein that promotes the growth and survival of brain cells.
- Huperzine A : This herbal extract is thought to improve cognitive function by blocking the breakdown of acetylcholine, a neurotransmitter important for memory. However, more research is needed to confirm its effectiveness.
- Phosphatidylserine : This compound is found in cell membranes and may help protect brain cells from damage. Some studies have shown that phosphatidylserine may improve cognitive function in people with Alzheimer's disease.
SECTION 5: Commonly marketed supplements:
- Omega-3 fatty acids: Omega-3 fatty acids are important for heart health and brain health. Studies have shown that people who eat more omega-3 fatty acids are less likely to die from heart disease and stroke. You can get omega-3 fatty acids from foods such as fatty fish, such as salmon, tuna, and mackerel, or from omega-3 fatty acid supplements.
- Magnesium: Magnesium is an important mineral for many bodily functions, including muscle and nerve function, blood sugar control, and blood pressure regulation. Studies have shown that people who are magnesium deficient are more likely to die from heart disease and stroke. You can get magnesium from foods such as leafy green vegetables, nuts, and seeds, or from magnesium supplements.
- Vitamin K: Vitamin K is important for blood clotting and bone health. Studies have shown that people who are vitamin K deficient are more likely to die from heart disease and stroke. You can get vitamin K from foods such as leafy green vegetables, broccoli, and Brussels sprouts, or from vitamin K supplements.
- Vitamin D: Vitamin D is important for bone health and immune function. It may also help to protect against cancer.
- Folate: Folate is a B vitamin that is essential for cell growth and repair. It is especially important for pregnant women, as folate deficiency can lead to birth defects.
- Iodine: Iodine is an essential mineral that is needed for the production of thyroid hormones. Thyroid hormones are important for many bodily functions, including metabolism and growth.
- Selenium: Selenium is a mineral that is important for many bodily functions. It may help to protect against cancer, heart disease, and Alzheimer's disease.
- Vitamin B12 : This vitamin is important for brain health. Some studies have shown that vitamin B12 may improve cognitive function in people with Alzheimer's disease.
SECTION 6: Common foods that increase longevity directly/indirectly:
- Coffee / Caffeine: Caffeine is a stimulant that has been shown to improve cognitive function and reduce the risk of some chronic diseases.
- Green tea: Green tea is a good source of antioxidants and has been shown to have a number of health benefits, including a reduced risk of heart disease and cancer. EGCG is a compound found in green tea. EGCG has been shown to improve cognitive function and reduce the risk of Alzheimer's disease.
- Olive oil: Olive oil is a healthy fat that has been shown to improve heart health and reduce the risk of some chronic diseases.
- Dark chocolate: Dark chocolate is a good source of antioxidants and has been shown to improve cognitive function and reduce the risk of heart disease.
- Lean protein: Lean protein is a good source of protein and other nutrients. It can help you maintain a healthy weight and reduce the risk of some chronic diseases.
- Aged garlic extract: Aged garlic extract is a supplement made from garlic that has been fermented. It has been shown to improve cognitive function and reduce the risk of Alzheimer's disease.
- Celery: Celery contains 3-n-butylphthalide, which has been shown to extend lifespan in animals.